Information
Research Projects in Progress:
- SCID mice model to study the interactions among peripheral blood monocytes, human periprosthetic tissue and bone tissue that lead to wear debris-associated loosening following total joint replacement.
- Combination gene therapy of anti-inflammation and counter-osteolysis for rheumatoid arthritis using a mouse collagen-induced arthritis model.
- A long-term murine model of prosthetic knee joint for implant stability, debris-associated bone resorption and potential gene therapy.
- Soluble VEGF receptor gene therapy in controlling growth and metastasis of osteosarcoma in a novel mouse model.
- Engineered bone graft substitutes for large bone defect. The study uses in intro and in vivo approaches to explore the type, composition, porosity, and biocompatibility of biomaterial scaffolds with the bedding and growth of osteo- and endothelial progenitor cells directional inducted from bone marrow stromal cells.
- Minocyclin-associated bone discoloration and its molecular mechanism.
Peer-Reviewed Papers (selected from last 6 years):
1. Yu H., P.J. VaneVord, L Mao, H.W. Matthew, P.H. Wooley, S-Y Yang (2008) Improved tissue-engineered bone regeneration by endothelial cell mediated
vascularization. Biomaterials doi:101016/j.biomaterials:2008.09.047
2. D. Yin, T. Jia, H. Yu, P.H. Wooley, M.P. Mott, S-Y Yang. (2008) VEGF Blockade Decelerates the Growth of a Murine Experimental Osteosarcoma.
Int J Oncol. 2008 Aug;33(2):253-9.
3. Yu H., B. Wu, L. Mayton, Z. Song, H.W. Matthew, P.J. VandeVord, P.H. Wooley, S-Y Yang(2008) Promotion of osteogenesis in tissue engineered bone by preseeding endothelial
progenitor cells-derived endothelial cells. J Orthop Res. 2008 Aug;26(8):1147-52.
4. Zhang L. Niu T. Yang S-Y. Chen B (2008). The occurrence and regional distribution of DR4 on herniated disc
cells: a potential apoptosis pathway in lumbar intervertebral disc. Spine. 2008 Feb;
33(4):422-7.
5. Yu, H., H. W. Matthew, P. H. Wooley, and S.-Y. Yang. (2008) Effect of Porosity and Pore Size on Microstructures and Mechanical Properties
of Poly-茠脮-Caprolactone-Hydroxyapatite Composites. J Biomed Mater Res B. 2008 Aug;86B(2):541-7.
6. Yang S-Y, H Yu, J E Krygier, P H Wooley, M P Mott. (2007) High VEGF with Rapid Growth and
Early Metastasis in a Mouse Osteosarcoma Model. Sarcoma 2007: 95628, 7 pages, doi:10.1155/2007/95628.
7. Zhang, T.; Gong, W.; Yang, S.; Zhang, K.; Yin, D.; Xu, P.; Jia, T. (2007) Efficacy of Hyperbaric Oxygen on Survival
of Random Pattern Skin Flap in Diabetic Rats. Undersea Hyperb. Med. 2007, 34, 335-339.
8. Yang, S.-Y., H. Yu, B. Wu, L. Mayton, R Costello, and P. H. Wooley (2007) A Murine Model of Prosthesis
Failure for the Long-term Study of Aseptic Loosening. J Ortho Res 2007 May;25(5):603-11.
9. Shang-You Yang and Paul H. Wooley (2006) Murine Air Pouch Model of Inflammation to Evaluate Orthopaedic
Wear Debris Associated Inflammation and Potential Inhibitory Cytokine Gene Therapy.
pp 155-168, Progress in Inflammation Research (Editor: Pitzer, James A)鈥 ISBN: 1-60021-008-2
10. Yang, S.-Y., B. Wu, L. Mayton, S. Nasser, D. C. Markel, and P. H. Wooley (2005) IL-1ra gene
transfer attenuates the inflammation of human periprosthetic tissues. J Bone & Joint
Surg 鈥揫AM] 87(5):1088-1097.
11. P. Mukherjee, S.-Y. Yang, B. Wu, Z. Song, L.K. Myers, P.D. Robbins, P.H. Wooley (2005) Tumor necrosis factor
receptor gene therapy affects cellular immune responses in collagen induced arthritis
in mice Ann Rheum Dis. 64:1550-1556
12. W. Ren*, S-Y. Yang*, P. H. Wooley (2004) A novel model of orthopaedic wear debris 鈥 associated osteolysis.
*Equal contribution Scand.J.Rheumatol 33(5):349-357.
13. Kallakuri S, Takebayashi T, Ozaktay AC, Chen C, Yang S, Wooley PH, Cavanaugh JM. (2004) The effects of epidural application of allografted
nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge.
Eur Spine J. 2004 Jul 28; [Epub ahead of print].
14. Yang, S.-Y., B. Wu, P. Mukherjee, L. Mayton, C. H. Evans and P. H. Wooley (2004) Protective
effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced
osteolysis. Gene Therapy 11(5):483-491 .
15. W. Ren, S-Y. Yang, Y. Park, S. Hsu, and P. H. Wooley (2003) Receptor activator of NF-茠脹B (RANK) and
RANK ligand (RANKL) expression in response to varying morphology of UHMWPE particles
in a murine model of inflammation Biomaterials. 24(26):4819-4826
16. S.-Y. Yang, L. Mayton, B. Wu, J. J. Goater, E. M. Schwarz, and P. H. Wooley (2002) Adeno-Associated
Virus-Mediated Osteoprotegerin Gene Transfer Protects against Particulate Polyethylene-Induced
Osteolysis in a Murine Model Arthritis & Rheumatism 46(9):2514-2523.
17. Yang, S-Y; W. Ren; Y. Park; S. Hsu; S. Nasser; and P. H. Wooley (2002) Diverse Cellular and
Apoptotic Responses to Variant Shapes of UHMWPE Particles in a Murine Model of Aseptic
Loosening Biomaterials 23(17):3535-3543
18. Yang S.-Y., B. Wu, L. Mayton, C. H. Evans, P. D. Robbins, S. Nasser and P. H. Wooley (2002) Retrovirus-Mediated
IL-10 And IRAP Gene Transfer Ameliorate The Local Inflammatory Reaction In A Murine
Model Of Inflammation. Inflamm. Res. 51(7): 342-350
19. Y.S. Park, S.Y. Yang, P.H. Wooley, K. Merritt, S. Hsu, M.J. McNallan (2001) Bioactivity Responses of Different
UHMWPE Particles from In-vivo and In-vitro Tests. Mat.Res.Soc.Symp.Proc. 662:381-386
20. Sud, S., S.-Y. Yang, C. H. Evans, P. D. Robbins and P. H. Wooley (2001) Effects of cytokine gene therapy
on particulate-induced inflammation in the murine air pouch. Inflammation 25: 361-372
21. Wooley, P. H., R. Morren, J. Andary, S. Sud, S.-Y. Yang, L. Mayton, D. Markel and S. Nasser (2002) Inflammatory responses to orthopaedic
biomaterials in the murine air pouch. Biomaterials 23(2):517-526
Published Abstracts (last 3 years)
1. S.-Y. Yang, Bin Wu, Lois Mayton, Paul H. Wooley (2004) Local Gene Transfer of OPG
Prevents Joint Damage and Disease Progression in Collagen-induced Arthritis Arthritis
Rheumat, 50:9(suppl):334
2. S.-Y. Yang; B. Wu; L. Mayton; R. Costello; H. Yu; and P. H. Wooley (2005) A murine
model of knee joint prosthesis failure for long-term study of aseptic loosening and
potential gene therapy. Orthopaedic Research Society Transactions, Vol.30:1220
3. H. Yu, S.-Y. Yang, P. H. Wooley (2005) Pore Size of Hydroxyapatite/Agarose Gel
Influences Viability of Bone Marrow Stromal Cells. Transactions of Society for Biomaterials,
Vol 30: 410
4. S.Y. Yang, B. Wu, L. Mayton, P. H. Wooley (2005). A SCID-Hu Mouse Model for Osteolytic-Associated
Prosthetic Joint Loosening Arthritis Rheumat, 52:9(suppl):S701
5. H.-N. Hao, S.-Y. Yang, P. H. Wooley (2005) Direct interaction of collagen II and
toll-like receptor depend upon the saccharide residues of collagen II: a potential
mechanism for collagen-induced arthritis. Arthritis Rheumat, 52:9(suppl):S477
6. H. Yu, P. H. Wooley, S.-Y. Yang (2006) Biocompatibility of PCL-HA hybrid with bone
marrow derived osteogenetic and vasculogenetic cells. Orthopaedic Research Society
Transactions, Vol.31: 830
7. Hao, H-N; Silver, R; Zheng, B; Yang, S-Y; Ren, W; Nasser, S; Wooley, P (2006) The
roles of monocytic heat shock protein 60 and toll-like receptor in response to wear
debris particles in aseptic loosing. Orthopaedic Research Society Transactions, Vol.31:
399
8. H. Yu, H.W. Mathew, C.D. Huber, P. H. Wooley, S.-Y. Yang (2006) Effect of porosity
and pore size on microstructures and mechanical properties of poly-a-caprolactone
(PCL)-hydroxyapatitie (HA) composites. Transactions of Society for Biomaterials, Vol
31: 499
9. S.-Y. Yang, J. Krygier, P. H. Wooley, M. P. Mott. High VEGF Expression Associates
with Early Tumor Development and Fast growth in a Novel Model of Osteosarcoma. (2006)
Transactions for Musculoskeletal Tumor Society2006: 43
10. S-Y Yang, B Zheng, H Yu, P D Robbins, H-N Hao, and P H Wooley. (2006) OPG or sTFNR
Gene Transfer Respectively Ameliorates the Disease Progression without Synergic Effects
in Collagen-induced Arthritis Arthritis Rheumat, 54:9(suppl):S242
11. Yu, H; Bin, W; Mayton, L; Song, Z; Wooley, P H; Yang, S-Y. (2007) Promote osteogenesis
in tissue engineered bone by pre-seeding endothelial progenitor cells-derived endothelial
cells. Orthopaedic Research Society Transactions, Vol.32: 347
12. Yang, S-Y; Yu, H; Wu, B; Krygier, J; Mott, M; Wooley, PH. (2007) High VEGF expression
associates with fast tumor development and early lung metastasis in a murine model
of Osteosarcoma. Orthop. Res. Soc. Transactions, Vol.32: 0983
13. H Yu; B Wu; L Mayton; Z Song; P. H. Wooley; S.-Y. Yang. (2007) Pre-Seeding Bone
Marrow Cells-Derived Endothelial Cells Promotes in vivo Osteogenesis of Bone Substitutes
Transactions of Society for Biomaterials, Vol 32: 61
14. H-N Hao, S-Y Yang, P. H. Wooley. (2007) Toll-Like Receptor Expression is Necessary
for Synovial Type II Cells to Respond to LPS: a Potential Mechanism of Reactive Arthritis
J. Immunol., 178: 101.14.
15. K. Zhang, T-H Jia, D. Yin, T. Zhang, D. Markel, P. H. Wooley, and S-Y Yang. (2008)
A SCID-Hu Chimera Model with Peripheral Blood Monocytes Transfusion for Osteolytic
Prosthesis Failure. Orthop. Res. Soc. Transactions Vol.33:1941.
16. H. Yu, H.W. Matthew, P.J. VandeVord, P.H. Wooley, S-Y Yang (2008) Improve Tissue-Engineered
Bone Regeneration by Introducing Endothelial Cells-Initiating Vascularization. Tissue
Engineering International & Regenerative Medicine Society (TERMIS_EU) Porto, Portugal
2008
17. K Zhang, D-Z Yin, T Jia, T Zhang, P Xu, H-N Hao, P Wooley, S-Y Yang. (2008) PMMA
and Ti Particles Promote Blood Monocytes Trafficking and Local Inflammation in a Mouse-Hu
Chimera of Aseptic Loosening. Arthritis Rheumat, 58:9(suppl):S1243
- 06/2008 鈥 now Senior Research Scientist Orthopaedic Research Institute, Via Christi Health System, 麻豆传媒映画出品, KS
- 10/2007 鈥 now Guest Professor Shandong University Affiliated Jinan Central Hospital, Jinan, China
- 09/2002 鈥 06/2008 Assistant Professor Department of Orthopaedic Surgery, School of Medicine, Wayne State University
- 01/2003 鈥 06/2008 Assistant Professor Department of Biomedical Engineering, College of Engineering, Wayne State University
- 03/1990 鈥 02/1994 Research Associate University of Manitoba, Winnipeg, Canada
- 08/1988 鈥 03/1990 Staff Surgeon in Orthopaedics Jinan Municipal Central Hospital, Shandong Province, China
Current Grant Support:
- 2007 - 2010 National Institute of Health (NIAM, 1R03AR054929): The study of gene therapy for aseptic loosening using a mouse implant model. Principle Investigator (PI)
- 2008-2010 Orthopaedic Research and Education Foundation (OREF): 鈥淐ell Trafficking in Debris-Associated Osteolysis鈥, PI
- 2008 鈥 2011 National Science Foundation (NSF) Developing a Biomimetric Approach Using a Hydroxyapatite-Collagen Composite for Load Bearing Orthopaedic Applications (PI: Dr. Pam VandeVord). Co-I
Institution and Location | Degree | Year | Field of Study |
---|---|---|---|
Shandong Medical College/Hong Wei Hospital, China | Diploma | Clinical Technology | |
Qingdao Medical College, China | MD | Clinical Medicine | |
Tianjin Medical University, China | Fellow | Orthopaedic rehabilitation | |
Thornhill University, Detroit | PhD | Biomedical Engineering | |
Wayne State University, Detroit | Post Doc | Vascular Biology | |
Wayne State University, Detroit | Post Doc | Orthopaedic Research |